Herein, we introduce a self-sensing piezoelectric tuning fork atomic force microscope (AFM) for molecular imaging on individual proteins. Thus, it is extremely interesting to find an alternative approach to resolve such type of problems. Also, optical artifacts and interferences are usually observed in liquid environment with the optical detection, and the laser beam alignment procedure can be an elaborate process in liquid environment. However, the optical beam deflection technique integrated in AFM presents some disadvantages such as the thermal drift due to cantilever elongation and bending caused by the heat dissipation of the laser diode. Most of the commercial AFM systems use the standard optical lever method of detection. Atomic force microscopy (AFM) has been widely used in biotechnological research to visualize proteins or cell components with a sub-nanometric resolution.
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